PPE1 — Magnaporthe oryzae 70-15

Summary

MoPPE1 (MGG_15748) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a protein methylesterase (EC 3.1.1.89) belonging to the alpha/beta hydrolase and PPase_methylesterase_euk families. The gene is associated with protein repair, TOR signaling, cellular detoxification, signal transduction, autophagy, and cell cycle processes, and its product localizes to the cytosol and nucleus. MoPPE1 is linked to numerous phenotypes including abnormal cell cycle progression (e.g., premature metaphase and telophase, G1 arrest), increased budding, decreased cell size, abnormal actin cytoskeleton and cellular morphology, increased mitophagy, decreased apoptosis, decreased ionic stress and alkaline pH resistance, increased chitin deposition, and decreased protein secretion. Studies of related genes in other species connect the family to increased filamentous growth, increased innate thermotolerance, increased oxidative stress resistance, and decreased starvation resistance.