CPR2 — Magnaporthe oryzae 70-15

Summary

MoCPR2 (MGG_15814) in Magnaporthe oryzae 70-15 encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) that binds cyclosporin A and exhibits cis-trans proline isomerase activity. The gene is associated with multiple biological processes including penetration peg formation, hyphal growth, MAPK cascade signaling, sumoylation, innate immunity, protein folding, and RNA metabolism. The encoded protein localizes to the endoplasmic reticulum lumen, cytoplasm, membrane, fungal-type vacuole, and extracellular space. Phenotypic associations link MoCPR2 to abnormal colony color, cell cycle arrest at metaphase-anaphase, altered endocytosis, increased cell death, abnormal nuclear transport, increased mitophagy, decreased invasive growth, altered pseudohyphal growth, decreased osmotic stress resistance, and increased sporulation efficiency. Studies of related cyclophilin family members in other species connect the family to acid sensitivity and increased stationary phase survival.