SET1 — Magnaporthe oryzae 70-15

Summary

MoSET1 (MGG_15053) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a histone-lysine N-methyltransferase specific for H3 lysine 4, possessing histone H3K4 trimethylase and methylase activities, and belongs to the Set1-like family. The gene is associated with appressorium formation, spore germination, ascus and ascospore development, cellular developmental processes, meiotic DNA double-strand break formation and its regulation, chromatin organization, rDNA heterochromatin assembly, telomeric silencing, telomere maintenance, homologous recombination, sterol homeostasis, phenotypic switching, translation initiation, and RNA processing. It localizes to the Set1C complex, chromosomes, and telomeric regions. Phenotypic associations include abnormal spore germination, increased sporulation rate, altered cell cycle progression through G2/M and G1/S transitions, delayed mitotic cell cycle, premature meiosis, and increased transposable element transposition. Studies of related genes in other species link the family to reduced virulence.