HIS3 — Magnaporthe oryzae 70-15

Summary

MoHIS3 (MGG_14904) on chromosome 6 of Magnaporthe oryzae 70-15 encodes a histidinol-phosphate transaminase (EC 2.6.1.9), a pyridoxal phosphate-dependent aminotransferase of the HisP_aminotrans family. The gene is associated with histidine anabolism, pigmentation, asexual reproduction, appressorium formation, morphogenesis, signal transduction, and phosphoglyceride metabolism, and its product localises to the cytosol. MoHIS3 is associated with abnormal mitochondrial transport and genome maintenance, decreased pexophagy, reticulophagy and mitophagy, altered liquid culture appearance, reduced respiratory growth and nitrogen utilisation, increased stress, metal and chemical resistance, increased replicative and chronological lifespan, altered protein accumulation, and variable competitive fitness. Studies of related genes in other species connect the family to oxidative stress response, endocytosis, vacuolar morphology, and vegetative growth.