CLM2 — Magnaporthe oryzae 70-15

Summary

MoCLM2 (MGG_14859) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a cytochrome P450 with heme and iron binding, oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen, and monooxygenase activity. The gene is associated with ergosterol and terpenoid biosynthesis, demethylation, mitophagy, sporulation, and hyphal growth, and its product localizes to membranes. Phenotypic associations link MoCLM2 to decreased micronucleophagy, nucleophagy, and ribophagy; absent hyperosmotic stress resistance and cytokinesis; abnormal plasma membrane morphology, cell cycle progression, and G0 entry; increased cell death and fermentative metabolism; and arrested vegetative and exponential-phase growth. The gene is also associated with decreased invasive growth, nutrient uptake, and utilization of iron and phosphorus sources, alongside increased lifespan and carbon source utilization. Related genes in other species include ERG11, linking the family to sterol biosynthesis.