SEC13 — Magnaporthe oryzae 70-15

Summary

MGG_14666 (SEC13, MoSEC13) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a protein belonging to the Sec13/Seh1 family, containing WD40 repeats, and has structural molecule activity. The gene is associated with COPII-coated vesicle budding, protein exit from the ER, nuclear pore localization, positive regulation of TOR signaling, autophagy, ERAD pathway, and lipid homeostasis. It localizes to the COPII vesicle coat, ER exit site, nuclear pore complex, and ER membrane. The gene is linked to rice blast disease. Associations include increased cell death, abnormal chitin deposition, decreased spore germination, abnormal nuclear transport, and decreased utilization of nitrogen source. Related genes in other species link the family to the GATOR2 complex and Nup84 complex.