CASB — Magnaporthe oryzae 70-15

Summary

MoCASB (MGG_13530) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a protein containing a Pept_C14_caspase domain and a Caspase-like_dom_sf domain, and is annotated with thiol endopeptidase activity. The gene is associated with apoptotic process, cell death, proteolysis, sporulation, morphogenesis, cell growth, and homeostasis, and its product localizes to the cytoplasm. Phenotypic associations include abnormal carbon source utilization, increased necrotic cell death, delayed sporulation, abnormal pseudohyphal growth, increased rates of cell cycle progression through G2/M and G1/S transitions, increased polyploidy, and altered budding, flocculation, and colony shape. The gene is also linked to blast disease in rice (Oryza sativa). Related genes in other species connect the metacaspase family to oxidative stress response, though pathogenicity is unaffected in those contexts.