CCR4 — Magnaporthe oryzae 70-15

Summary

MoCCR4 (MGG_13020) in Magnaporthe oryzae 70-15 encodes a cytoplasmic deadenylase with poly(A)-specific RNase and 3'-5' exoribonuclease activity (EC 3.1.13.4), belonging to the endo/exonuclease/phosphatase superfamily and containing leucine-rich repeats. The gene is associated with carbon catabolite repression, nuclear-transcribed mRNA poly(A) tail shortening, appressorium formation, invasive growth, hyphal growth, cell development, DNA replication checkpoint, and positive regulation of transcription elongation by RNA polymerase II. It localises to the CCR4-NOT core complex, Paf1 complex, P bodies, cytoplasm, and nucleus. Phenotypic associations link MoCCR4 to increased virulence, increased sporulation, decreased cell death rate, abnormal cell cycle progression, premature G2/M phase transition, and delayed exit from stationary phase. Related genes in other species are associated with oxidative stress response and zinc sensitivity.