DIN1 — Magnaporthe oryzae 70-15

Summary

MoDIN1 (MGG_12119) on chromosome 6 of Magnaporthe oryzae 70-15 encodes a decapping nuclease with 5'-hydroxyl dinucleotide hydrolase, RNA NAD-cap hydrolase, mRNA 5'-diphosphatase and phosphodiesterase decapping endonuclease activities, and belongs to the RAI1-like family. The gene is associated with NAD-cap decapping, deadenylylation-independent decapping, nuclear mRNA breakdown, rRNA processing, innate immunity, and cell death. Its product localises to the nucleus, cytosol and the Las1 complex. MoDIN1 is associated with numerous cellular phenotypes including absent filamentous growth, decreased cell death, altered cell cycle progression, increased vegetative growth rate, increased acid pH resistance, decreased cold sensitivity, and abnormal peroxisomal morphology. Related genes in other species connect the family to ribosome biogenesis and RNA metabolism.