GLR1 — Magnaporthe oryzae 70-15

Summary

MGG_12749 (MoGLR1) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a protein with a GSHR/TRXR-like domain and glutathione reductase activity (EC 1.8.1.7), also annotated as dihydrolipoyl dehydrogenase (NADH) activity. The gene is associated with cellular oxidant detoxification, cell redox homeostasis, and the pyruvate dehydrogenase and 2-oxoglutarate metabolism pathways. It is linked to the mitochondrial lumen, peroxisome, and fungal biofilm matrix. MoGLR1 is associated with increased respiration rate, altered cell cycle progression (including increased G2/M transition and delayed metaphase-anaphase), increased anaerobic and pseudohyphal growth, increased freeze-thaw and osmotic stress resistance, decreased apoptosis, and abnormal colony color, Golgi morphology, and peroxisomal transport. Related genes in other species link it to glutathione reductase function and oxidative stress response.