DER1 — Magnaporthe oryzae 70-15

Summary

MoDER1 (DER1) of Magnaporthe oryzae 70-15, located on chromosome 6, encodes a Derlin-family protein localised to the ER membrane. The gene is associated with the ERAD pathway, ER stress response, ER-phagy, autophagy, autophagic cell death, protein secretion and folding, septin ring assembly, hyphal growth, asexual reproduction, morphogenesis, and general stress responses. Phenotypic associations link MoDER1 to altered cell death (both increased and decreased), abnormal autophagy and mitophagy, defective nuclear import and cell cycle arrest, increased aneuploidy, abnormal Golgi and cell wall morphology, altered protein secretion and transport, and increased lifespan. Related genes in other species connect it to ER-associated degradation and the CDC48 complex.