CPR1 — Magnaporthe oryzae 70-15

Summary

MoCPR1 (MGG_11257) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase, EC 5.2.1.8) that binds cyclosporin A and exhibits cis-trans proline isomerase activity. The gene is associated with penetration peg formation, hyphal growth, protein folding and refolding, sumoylation, and mRNA splicing via the spliceosome. Its product localises to the spindle pole body, cytoplasm, cytosol, and nucleus. Phenotypic associations include altered sporulation, colony size, meiotic recombination, cell cycle progression, cytokinesis, pseudohyphal growth, flocculation, vacuolar transport, osmotic stress resistance, nutrient uptake, and chemical resistance. The gene is also linked to abnormal spore wall formation, increased fermentative growth, and altered RNA accumulation and silencing. Studies of related genes in other species connect the family to sporulation timing, vegetative growth, biofilm formation, and freeze-thaw resistance.