HSCA — Magnaporthe oryzae 70-15

Summary

MoHSCA (MGG_11513) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a member of the Hsp70 family of molecular chaperones, possessing ATP hydrolase activity, ATP binding, heat shock protein binding, and protein folding chaperone functions, and is annotated with EC 3.6.4.10. The gene is associated with a wide range of biological processes including protein folding and refolding, ribosome biogenesis, translation, autophagy, macroautophagy, regulation of autophagy, appressorium formation, the ER stress response, nuclear export, and multidomain protein assembly. It is linked to the cytoplasm, cytosol, nucleus, plasmalemma, and the fungal biofilm matrix. Associations with traits include abnormal spore germination, altered cell cycle progression, and increased thermotolerance. Studies of related genes in other species link the family to protein content.