MGM1 — Magnaporthe oryzae 70-15

Summary

MGG_11902 (MoMGM1) on chromosome 1 of Magnaporthe oryzae 70-15 encodes a dynamin GTPase, a member of the dynamin family characterized by GTPase, stalk, and GED domains. The encoded protein exhibits GTPase activity, membrane fusion GTPase activity, membrane scission GTPase motor activity, membrane bending activity, and binds cardiolipin, phosphatidate, phosphatidylserine, PtdIns(3,5)P2, microtubules, lipids, GTP, and metals. MoMGM1 is associated with mitochondrial outer and inner membrane fusion, mitochondrial membrane fission, cristae formation, vesicle scission, autophagic cell death, defense response, photosynthesis, jasmonic acid anabolism, and heme transport. It localizes to mitochondrial membranes, cristae, microtubules, peroxisomes, vacuole membranes, and cell division sites. Phenotypic associations link MoMGM1 to decreased oxidative phosphorylation, abnormal mitochondrial distribution, absent filamentous growth, increased cell death, increased lifespan, and altered stress resistance. Studies of related genes in other species connect the family to oxidative stress response.