GCN5 — Magnaporthe oryzae 70-15

Summary

MGG_11716 (MoGCN5) encodes a protein with GNAT and bromodomain domains, and has histone H3K9, H3K14, H3K18 and H4K16 acetyltransferase activities as well as histone crotonyltransferase and reader activities. In Magnaporthe oryzae, MoGCN5 is associated with appressorium formation, asexual reproduction and sporulation, carbon catabolite repression, glycogenolysis, melanin anabolism, macroautophagy, programmed cell death, and DNA repair-dependent chromatin remodeling. The protein localises to the nucleus, cytoplasm, chromatin, centromere complex, and the ADA, SALSA and SWR-C complexes. Related genes in other species link the family to virulence, oxidative stress response, and ion homeostasis. MoGCN5 is also associated with increased rates of RNA accumulation, sporulation, nutrient uptake, and cell cycle progression through G1/S and G2/M transitions.