PEX5 — Magnaporthe oryzae 70-15

Summary

MGG_10840 (MoPEX5) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a member of the PEX5/PEX5L family containing tetratricopeptide repeat (TPR) domains. The encoded protein exhibits PTS1 binding, protein carrier activity, and protein binding, bridging, and is associated with peroxisome matrix protein import and docking, protein-peroxisome targeting, fatty acid beta-oxidation, fatty acid metabolism, and morphogenesis. It localises to the peroxisomal import pore, peroxisomal lumen, peroxisome membrane, peroxisome, and cytosol. The gene is associated with numerous phenotypes including abnormal peroxisomal morphology and distribution, absent peroxisomal transport, increased pheromone sensitivity and mating response, altered cell cycle progression, increased budding, decreased chitin deposition, and increased lifespan. Studies of related genes in other species connect the family to additional peroxisomal import factors such as PEX7, PEX12, and PEX13.