GIS1 — Magnaporthe oryzae 70-15

Summary

MoGIS1 (MGG_09186) on chromosome 1 of Magnaporthe oryzae 70-15 encodes a histone demethylase with activity toward H3K4, H3K9, and H3K36, and also functions as a histone reader and DNA-binding protein. It contains JmjN, JmjC, EPHD, PHD, and RING/FYVE/PHD zinc-finger domains. The gene is associated with appressorium formation, host invasion, DNA damage response, DNA replication, mismatch repair, chromatin remodeling, and regulation of transcription by RNA polymerase II. It localizes to the nucleus, cytoplasm, chromatin, and the NuA3b and Mst2 histone acetyltransferase complexes. MoGIS1 is linked to turgor pressure, oxidative stress response, and numerous phenotypes including abnormal spore germination, altered budding patterns, increased necrotic cell death, increased freeze-thaw and hydrostatic pressure resistance, decreased adhesion, and impaired utilization of nitrogen sources.