FRDA — Magnaporthe oryzae 70-15

Summary

MGG_09226 (MoFRDA) encodes a fumarate reductase (NADH) with FMN binding, belonging to the flavocytochrome c and succinate dehydrogenase/fumarate reductase catalytic domain families. In Magnaporthe oryzae, MoFRDA is associated with appressorium formation and maturation, host invasion, conidiophore development, asexual reproduction, pigmentation, cell development, autolysis, TORC2 signaling, negative regulation of autophagy, defense response, UMP anabolism, fumarate metabolism, response to AOS, osmotic response, and nucleosome assembly. The protein localizes to mitochondria, cytoplasm, cytosol, and nucleus. MoFRDA is linked to traits including turgor pressure, germination rate, and oxidative stress response, and to phenotypes such as decreased anaerobic growth and fermentative metabolism, increased acid pH resistance and hyperosmotic stress resistance, increased cell death and mitophagy, and abnormal mitochondrial genome maintenance.