ATG5 — Magnaporthe oryzae 70-15

Summary

MGG_09262 (ATG5, MoATG5) on chromosome 1 of Magnaporthe oryzae 70-15 encodes a protein with Atg5_HR and Atg5_UblA_dom domains and APG8 ligase activity. It is associated with autophagy, mitophagy, aggrephagy, appressorium formation and maturation, hyphal growth, cell differentiation, cellular response to nitrogen starvation, glycogen metabolism, UMP anabolism, RNA methylation, sumoylation, detoxification, protein transport, and cellular homeostasis. The gene product localises to the Atg12-Atg5-Atg16 complex, phagophore, PAS membrane, and mitochondria-associated membrane. Associations with oxidative stress response, delayed autophagy, abnormal nucleophagy, decreased ribophagy and pexophagy, absent mitophagy, and increased mating response have been noted. Related genes in other species are linked to reduced virulence.