PARP — Magnaporthe oryzae 70-15

Summary

MoPARP (MGG_08613) on chromosome 1 of Magnaporthe oryzae 70-15 encodes a poly(ADP-ribose) polymerase (PARP) family protein with NAD ADP-ribosyltransferase and protein ADP-ribosylase activities (EC 2.4.2.30). The product contains catalytic, regulatory, WGR, and BRCT domains and binds DNA and zinc. It is associated with protein poly-ADP-ribosylation, DNA repair including double-strand break repair, upregulation of DNA repair, and cell death, and localises to the nucleolus. The gene has been connected to blast disease in rice (Oryza sativa). Studies of related PARP family members in other species link the family to similar DNA-damage response and cell-death processes, though these associations are not yet established for MoPARP itself.