ABC2 — Magnaporthe oryzae 70-15

Summary

MoABC2 (MGG_08309) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a multidrug resistance-associated protein 2, an ABC transporter with ATP-binding and transmembrane domains. The gene product exhibits cadmium ion transmembrane transporter, haem-transporting ATPase, and ABC-type phytochelatin and xenobiotic transporter activities, and binds ATP, heme, and metals. MoABC2 is associated with heme export from the vacuole to the cytoplasm, cellular detoxification of cadmium ions, glutathione and PC2 import into the vacuole, response to metal and toxic substances, host invasion and interaction, cell wall biogenesis, secondary metabolism, and siRNA-mediated post-transcriptional gene silencing. It localizes to the vacuolar membrane, extracellular vesicles, Golgi complex, and plasma membrane. The gene is linked to abnormal vacuolar morphology and distribution, altered cell cycle progression, decreased endocytosis, and increased pexophagy and entry into G0 stationary phase.