ERG8 — Fusarium odoratissimum str. race 4

Summary

FoERG8 (FOC4_G10011679) on chromosome KB726997 of Fusarium odoratissimum str. race 4 encodes a phosphomevalonate kinase, an enzyme with ATP-binding activity that acts in the mevalonate and isoprenoid pathways. The gene is associated with ergosterol and sterol anabolism, spore germination, and the electron transport chain. Its product localises to the peroxisome, mitochondria, cytosol and nucleus. Associations with numerous phenotypes have been recorded, including decreased vegetative growth, increased chronological lifespan, altered stress resistance (increased oxidative stress resistance, decreased desiccation resistance), altered toxin resistance, abnormal vacuolar morphology, decreased competitive fitness, and auxotrophy. The gene is also linked to responses to hydrogen peroxide, heat, and salt stress in the context of the TR4 pathogen. Studies of related genes in other species connect the family to nucleolar size, mitochondrial morphology and starvation resistance.