ERG6 — Fusarium odoratissimum str. race 4

Summary

FoERG6 (FOC4_G10012182) on chromosome KB726997 of Fusarium odoratissimum str. race 4 encodes a sterol 24C-methyltransferase, a member of the methyltransferase family with MeTrfase_SMT and Sterol_MeTrfase_C domains. The enzyme is associated with ergosterol and sterol biosynthesis, methylation, spore germination, and the electron transport chain. It localises to the endoplasmic reticulum, mitochondria, nucleus, and adiposomes. The gene is linked to numerous cellular processes including abnormal filamentous growth, plasma membrane morphology, endocytosis, vacuolar transport, cell cycle progression, and increased polyploidy and aneuploidy. It is also associated with absence of anaerobic growth and micronucleophagy, and altered pheromone sensitivity and mating projection morphology. Studies of related genes in other species link the family to reduced virulence and cell membrane stability.