ERG26 — Fusarium odoratissimum str. race 4

Summary

FoERG26 (FOC4_G10015396) from Fusarium odoratissimum str. race 4 encodes a 3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase, a member of the 3Beta_OHSteriod_DH/Estase family with a NAD(P)-binding domain. This enzyme is associated with ergosterol and sterol anabolism, the electron transport chain, and spore germination. It localizes to the endoplasmic reticulum and Golgi complex. The gene is linked to numerous phenotypes including decreased spore germination, increased cell death and apoptosis, abnormal plasma membrane and ER morphology, decreased invasive growth, altered nutrient uptake, and reduced alkaline pH resistance. It is also connected to responses to hydrogen peroxide, Congo red, temperature stress, and salinity. Studies of related genes in other species link the family to sterol biosynthesis and related cellular processes.