ERG26 — Fusarium odoratissimum str. race 4

Summary

FOC4_G10003494 (ERG26) on chromosome KB726963 of Fusarium odoratissimum str. race 4 encodes a protein with a 3Beta_OHSteriod_DH/Estase domain and a NAD(P)-bd_dom_sf domain. It has 3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity, C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity, and oxidoreductase activity acting on the CH-OH group of donors with NAD or NADP as acceptor. The gene is associated with spore germination, electron transport chain, sterol anabolism, and ergosterol anabolism. Its product localises to the endoplasmic reticulum and Golgi complex. ERG26 is also linked to responses under NaCl stress and at 28°C in the FoTR4 strain. Studies of related genes in other species connect the family to the same sterol dehydrogenase/decarboxylase activity (EC 1.1.1.170).