EXO70 — Fusarium odoratissimum str. race 4

Summary

FoEXO70 (FOC4_G10006795) from Fusarium odoratissimum str. race 4 encodes a protein containing an Exo70_C domain and a cullin-repeat-like domain superfamily, with molecular functions including phosphatidylinositol-4,5-bisphosphate binding and small GTPase binding. The gene is associated with exocyst assembly and localization, Rho protein signal transduction, Golgi-to-plasma membrane transport, protein secretion, and exocytosis. The encoded protein localizes to the exocyst, plasma membrane, cellular bud tip, bud neck, and incipient bud site. Phenotypic associations include abnormal filamentous growth, budding, septum formation, chitin deposition, spore wall formation, and vesicle distribution; increased thermotolerance and mating efficiency; decreased cell fusion, pheromone production, pexophagy, and necrotic cell death; and altered cell cycle progression, shmoo formation, and intracellular transport. Related genes in other species link the EXO70 family to Rho4, Cdc42, and exocyst components.