RPB2 — Fusarium odoratissimum str. race 4

Summary

FoRPB2 (RPB2, FOC4_G10009029) on chromosome KB726312 of Fusarium odoratissimum str. race 4 encodes a protein containing multiple RNA polymerase Rpb2 domains and a DNA-directed RNA polymerase subunit 2 family domain. The product possesses DNA-directed RNA polymerase activity, RNA-dependent RNA polymerase activity, and ribonucleoside, RNA, DNA and zinc binding. It is associated with transcription initiation, elongation and termination by RNA polymerases I, II and III, snRNA transcription, RNAi-mediated heterochromatin assembly at centromeres, and translation elongation. Localisation evidence places the protein in the nucleus, cytosol, chromatin, centric heterochromatin and all three RNA polymerase complexes. The gene is linked to numerous phenotypes including abnormal cell cycle progression, decreased meiosis and meiotic recombination, increased aneuploidy, decreased radiation resistance, abnormal fermentative and respiratory metabolism, absent silencing and transposable element transposition, and altered spore wall formation, bud neck morphology and shmoo formation.