RGA1 — Fusarium odoratissimum str. race 4

Summary

FoRGA1 (RGA1) on chromosome KB726997 of Fusarium odoratissimum race 4 encodes a protein with a Znf_LIM domain, a RhoGAP domain and Rho GTPase activation protein family membership, and is annotated with small GTPase binding, GAP activity, GDS, lipid binding, and metal binding molecular functions. The gene is associated with regulation of actin cable assembly, positive regulation of bipolar cell polarity, mitotic division septum assembly, regulation of cell wall organization, negative regulation of the cell integrity MAPK cascade, and small GTPase-mediated signal transduction. It localizes to the cleavage furrow, cellular bud, actomyosin contractile ring layers, growing cell tip and site of polarized growth. Phenotypic associations include abnormal bipolar budding, decreased septum formation, decreased flocculation, altered cell cycle progression, abnormal filamentous growth, absent hyperosmotic stress resistance, and sterility. Related genes in other species link the family to bipolar budding and cell polarity establishment.