GCN5 — Fusarium odoratissimum str. race 4

Summary

FoGCN5 (GCN5) on chromosome KB726996 of Fusarium odoratissimum str. race 4 encodes a protein with GNAT and bromodomain families. It exhibits histone H3K18, H3K9, H3K14, and crotonyltransferase activities, and reads H4K16ac, H4K12ac, and H3K56ac marks. The gene is associated with DNA repair-dependent chromatin remodeling, positive regulation of transcription elongation by RNA polymerase II, regulation of DNA-templated transcription, cellular response to xenobiotic stimulus, and chromatin-mediated maintenance of transcription. It localizes to the nucleus, cytoplasm, chromatin, and complexes including ADA, SALSA, and SWR-C. FoGCN5 is linked to increased sporulation, nutrient uptake, carbon source utilization, and fermentative growth, as well as abnormal mitophagy, cell cycle progression, and chronological lifespan. Studies of related genes in other species connect the family to altered virulence, including hypervirulence and loss of pathogenicity.