ERG6 — Fusarium odoratissimum str. race 4

Summary

FoERG6 (FOC4_G10001049) on chromosome KB726203 of Fusarium odoratissimum f. sp. cubense TR4 encodes a sterol 24C-methyltransferase. The gene is associated with sterol and ergosterol anabolism, methylation, spore germination, the electron transport chain, and localisation to the endoplasmic reticulum, mitochondria and adiposomes. It is linked to a wide range of cellular phenotypes including abnormal filamentous growth, plasma membrane and ER morphology, delayed shmoo formation and cell fusion, decreased endocytosis and pheromone sensitivity, increased polyploidy and aneuploidy, absent anaerobic and hyperosmotic stress resistance, and altered cell cycle progression and cell death. Studies of related genes in other species connect the family to reduced virulence and traits such as cell membrane stability and oxidative stress response.