ERG6 — Fusarium odoratissimum str. race 4

Summary

FoERG6 (FOC4_G10001050) on chromosome KB726203 of Fusarium odoratissimum f. sp. cubense TR4 encodes a sterol 24C-methyltransferase of the MeTrfase_SMT family. The gene is associated with zymosterol metabolic process, ergosterol anabolism, spore germination, electron transport chain, and cellular response to xenobiotic stimulus. Its product localises to the endoplasmic reticulum, plasma membrane, mitochondria and adiposomes. FoERG6 is linked to numerous cellular phenotypes including abnormal filamentous growth, altered cell cycle progression, increased polyploidy and aneuploidy, decreased endocytosis, vacuolar transport, loss of hyperosmotic stress resistance, and absence of anaerobic growth and micronucleophagy. Studies of related genes in other species connect the family to reduced virulence and cell membrane stability.