ERG6 — Fusarium odoratissimum str. race 4

Summary

FoERG6 (FOC4_G10001051) on chromosome KB726203 of Fusarium odoratissimum str. race 4 encodes a sterol 24C-methyltransferase, a member of the SAM-dependent methyltransferase superfamily with MeTrfase_SMT and Sterol_MeTrfase_C domains. The enzyme is annotated for sterol 24C-methyltransferase activity and identical protein binding, and is associated with ergosterol and sterol anabolism, methylation, spore germination, and the electron transport chain. It localises to the endoplasmic reticulum, mitochondria, and adiposomes. The gene is linked to numerous phenotypes including abnormal filamentous growth, decreased cell death, increased polyploidy and aneuploidy, altered endocytosis, vacuolar transport defects, and loss of hyperosmotic stress resistance and anaerobic growth. It is also connected to hydrogen peroxide stress responses in the Fusarium oxysporum f. sp. cubense TR4 pathosystem. Studies of related genes in other species link the family to reduced virulence and traits such as cell membrane stability and oxidative stress response.