GLT1 — Fusarium odoratissimum str. race 4

Summary

FoGLT1 (FOC4_G10007142) in Fusarium odoratissimum race 4 encodes a glutamate synthase (NADH) with oxidoreductase activity, containing domains for FAD/NAD binding, FMN binding, 3Fe-4S cluster binding, and iron binding. The gene is associated with the ammonia assimilation cycle and L-glutamate biosynthesis, and its product localises to the mitochondrial lumen and cytosol. FoGLT1 is associated with decreased sporulation efficiency, abnormal mitochondrial and endomembrane system morphology, absent autophagy and pexophagy, decreased hypoosmotic and UV resistance, increased hyperosmotic stress resistance, and altered fermentative and respiratory growth rates. It is also linked to differential expression under Congo Red stress and various TR4 strain conditions. Studies of related genes in other species further link the family to .