SKP1 — Fusarium odoratissimum str. race 4

Summary

FoSKP1 (SKP1) on chromosome KB726990 of Fusarium odoratissimum str. race 4 encodes a protein with a SKP1-like dimerisation domain and is annotated for cullin family protein binding and ligase activity. The gene is associated with protein ubiquitination, ubiquitin-dependent proteolysis, and SCF-dependent proteasomal ubiquitin-dependent protein breakdown, as well as regulation of DNA recombination, resolution of meiotic recombination intermediates, mitotic cell cycle, and mitotic nuclear membrane biogenesis. It is linked to numerous cell cycle phenotypes, including premature anaphase progression, altered G1/S and G2/M transitions, decreased M-phase progression, and increased rate of passage through START. Associations also include decreased flocculation, abnormal bipolar budding, abnormal pseudohyphal growth, delayed sporulation, and increased mating efficiency. Studies of related genes in other species link the gene family to loss of pathogenicity and oxidative stress response.