NRF1 — Fusarium odoratissimum str. race 4

Summary

FoNRF1 (FOC4_G10013936) in Fusarium odoratissimum race 4 encodes a protein with polyphosphate kinase and GTPase regulator activities, binds ATP and metal ions, and belongs to the DUF202 domain family. It is associated with polyphosphate import into the vacuole, polyphosphate anabolism, energy reserve metabolism, protein secretion, exocytosis, and vacuolar transport. The gene product localises to the VTC complex, fungal-type vacuole membrane, cell division site, and endoplasmic reticulum. Phenotypic associations include decreased chemical compound accumulation and transport, delayed protein secretion and vacuolar transport, abnormal ER and Golgi distribution, premature cell cycle progression through G2/M and anaphase, increased necrotic cell death, and delayed sporulation. Studies of related genes in other species link the family to phosphate content and zinc sensitivity.