NTH1 — Fusarium odoratissimum str. race 4

Summary

FoNTH1 (FOC4_G10014001) on chromosome KB726993 of Fusarium odoratissimum f. sp. cubense TR4 encodes a trehalase with alpha,alpha-trehalase activity and calcium ion binding, belonging to the Glyco_hydro_37 family. The gene is associated with mycose catabolism and metabolism, regulation of protein secretion, ascospore formation, and cellular responses to heat and starvation. It is linked to increased acquired thermotolerance and freeze-thaw resistance, absent biofilm formation and hyperosmotic stress resistance, and altered cell cycle progression, including premature metaphase and telophase progression and increased G2/M phase transition. Associations also include increased flocculation, abnormal budding patterns, and decreased ribophagy and nuclear import. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.