RPB1 — Fusarium odoratissimum str. race 4

Summary

FoRPB1 (RPB1) on chromosome KB726996 of Fusarium odoratissimum race 4 encodes a protein with RNA polymerase Rpb1 domains and a eukaryotic RNA polymerase II repeat. The product has DNA-directed RNA polymerase activity, chromatin adaptor function, DNA binding, and metal binding. FoRPB1 is associated with transcription initiation and elongation by RNA polymerases I, II and III, mRNA capping, co-transcriptional lncRNA 3'-end processing, and intracellular phosphate homeostasis. It localises to the nucleus, nucleolus, chromatin, cytosol, and RNA polymerase I, II and III complexes. The gene is linked to increased virulence, altered cell cycle progression, increased sporulation rate, decreased polyploidy, abnormal mitophagy, increased transposable element transposition, and altered pheromone sensitivity. Related genes in other species are linked to reduced virulence, oxidative stress response, and acid sensitivity.