ERG26 — Fusarium odoratissimum str. race 4

Summary

FoERG26 (FOC4_G10014128) on chromosome KB726996 of Fusarium odoratissimum str. race 4 encodes a protein with 3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity, UDP-glucose 4,6-dehydratase activity, DTDP-glucose 4,6-dehydratase activity, C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity, and oxidoreductase activity acting on the CH-OH group of donors with NAD or NADP as acceptor, placing it in the 3Beta_OHSteriod_DH/Estase and NAD(P)-bd_dom_sf families. The gene is associated with ergosterol and sterol biosynthesis, rhamnose anabolism, nucleotide-sugar metabolism, spore germination, and the electron transport chain. Its product localises to the Golgi complex and ER. Expression of FoERG26 has been linked to responses to hydrogen peroxide, high temperature (35°C), salt stress (NaCl), and the fungal strains NK51 and BX51. Studies of related genes in other species connect the family to unaffected pathogenicity, though this has not been established for FoERG26 itself.