RNR1 — Fusarium odoratissimum str. race 4

Summary

FoRNR1 (FOC4_G10012850) on chromosome KB726554 of Fusarium odoratissimum race 4 encodes a ribonucleoside-diphosphate reductase large subunit, possessing CDP reductase activity and ATP binding, and is a component of the RNR complex localised to the cytoplasm and cytosol. The gene is associated with deoxyribonucleotide and DNA anabolism, CDP metabolism, and regulation of DNA anabolism. Phenotypic associations link FoRNR1 to cell cycle progression, particularly S phase and G1/S and G2/M transitions, as well as meiotic recombination, telomere length, mitochondrial genome maintenance, and responses to gamma ray and UV exposure. Additional associations include vegetative growth, chronological lifespan, and resistance to chemicals. Studies of related genes in other species connect the family to oxidative stress response and acid sensitivity.