SEC4 — Fusarium odoratissimum str. race 4

Summary

FOC4_G10011882 (FoSEC4) on chromosome KB726997 encodes a small GTPase with GTPase activity and GTP binding. It is associated with the regulation of protein secretion, vesicle-mediated transport, exocytosis, and cytokinesis, as well as protein localization to the cell tip and spindle pole body. The gene product localizes to the transport vesicle membrane, Spitzenkorper, cleavage furrow leading edge, and growing cell tip. Phenotypic associations include decreased rates of cytokinesis and vacuolar transport, abnormal filamentous growth, delayed sporulation, and absent oxidative stress resistance. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence, and sequence similarity connects FoSEC4 to fusarium wilt in banana and other hosts.