SOD2 — Verticillium dahliae

Summary

VDAG_10207 (SOD2, VdSOD2) in Verticillium dahliae encodes a manganese/iron superoxide dismutase (Mn/Fe SOD) with superoxide dismutase activity, manganese binding and IgE binding functions. The enzyme localises to the mitochondrial lumen, mitochondria and cytosol, and is associated with removal of O2-, evasion or tolerance of host-produced AOS, oxidative phosphorylation, detoxification, morphogenesis and homeostasis. The gene is associated with photosynthetic rate and with numerous phenotypes including altered respiratory metabolism, increased necrotic cell death, abnormal septum and spore wall formation, increased hydrostatic pressure and freeze-thaw resistance, decreased radiation and pheromone sensitivity, and altered cell cycle progression and stationary phase entry. Studies of related genes in other species connect the family to oxidative stress response, sodium concentration, manganese content and acid sensitivity.