PTC3 — Verticillium dahliae

Summary

VDAG_00016 (PTC3) in Verticillium dahliae encodes a protein with PP2C and PPM-type phosphatase domains, exhibiting MAP kinase serine/threonine phosphatase activity, adenylyl cyclase activity, and binding to magnesium and ATP. This gene is associated with conidium development, downregulation of MAPK and p38 cascades, cAMP anabolism, the endoplasmic reticulum unfolded protein response, cellular osmotic response, intracellular signal transduction, and fungal-type cell wall organization. The product localizes to the cytoplasm, cytosol, and nucleus. Related genes in other species are linked to loss of pathogenicity and oxidative stress response, though these associations are not yet established in V. dahliae itself.