PHB1 — Verticillium dahliae

Summary

VDAG_00218, designated VdPHB1 (synonym PHB1) in Verticillium dahliae on chromosome DS572695, encodes a prohibitin family protein containing Band_7 and SPFH domains. The product is annotated as a mitophagy receptor and localises to the mitochondrial inner membrane and cytoplasm. VdPHB1 is associated with inner mitochondrial membrane organisation, mitochondrial biogenesis, mitochondrion inheritance, protein folding, programmed cell death, mitophagy, and downregulation of proteolysis. Phenotypic associations include delayed vegetative growth, decreased lifespan, increased apoptosis rate, decreased oxidative phosphorylation, increased adhesion, altered colony colour, and increased resistance to alkaline pH and hydrostatic pressure. The gene is also linked to increased entry into G0 phase, increased cell cycle progression in G1, decreased nuclear import, and altered fermentative metabolism. Studies of related genes in other species connect the family to reduced virulence and oxidative stress response.