ARG5 — Verticillium dahliae

Summary

VDAG_00348, also known as VdARG5, VdCPA1 or ARG5, encodes a carbamoyl-phosphate synthase (glutamine-hydrolyzing) (EC 6.3.5.5) that belongs to the anthranilate synthase/amidotransferase and carbamoyl-phosphate synthase small subunit families. The enzyme possesses glutaminase activity and ATP binding, and is associated with glutamine metabolism, de novo pyrimidine base anabolism, and arginine anabolism. The protein localises to the carbamoyl-phosphate synthase complex, the mitochondrial lumen, and the cytoplasm. Studies of related genes in other species link the family to reduced virulence.