FLBA — Verticillium dahliae

Summary

VdFLBA (VDAG_00683) in Verticillium dahliae encodes a protein with GTPase-activating protein (GAP) activity, containing regulator of G-protein signaling (RGS) and DEP domains, and is localized to the cytoplasm, nucleus, and internal side of the plasma membrane. The gene is associated with negative regulation of GPCR signaling, downregulation of signal transduction, the pheromone response MAPK cascade, regulation of conidium formation, asexual sporulation, sterigmatocystin biosynthesis and breakdown, morphogenesis, and transcription by RNA polymerase II. Phenotypic associations link VdFLBA to abnormal mating response and pheromone sensitivity, altered shmoo formation, increased chemical compound excretion, absent osmotic stress resistance, increased endocytosis, decreased necrotic cell death, and abnormal replicative lifespan, vegetative growth, and nuclear transport.