ALA1 — Verticillium dahliae

Summary

VDAG_00937, designated VdALA1, encodes an alanine-tRNA ligase (EC 6.1.1.7) with alanine-tRNA ligase activity, aminoacyl-tRNA editing activity, tRNA binding, ATP binding, and zinc binding. The enzyme is localized to the cytoplasm, cytosol, mitochondria, and mitochondrial lumen, and is associated with mitochondrial and cytoplasmic alanyl-tRNA aminoacylation as well as detoxification. VdALA1 is linked to numerous cellular processes including cell cycle progression through G1/S and G2/M transitions, budding, cell morphology and size, mitochondrial genome maintenance and morphology, nuclear morphology and export, telomere length, autophagy, cold sensitivity, freeze-thaw resistance, chemical resistance, respiratory metabolism, endomembrane system morphology, RNA accumulation and localization, protein/peptide modification and accumulation, and silencing. Studies of related genes in other species connect the family to cell cycle arrest at START and decreased oxidative stress resistance.