HSCA — Verticillium dahliae

Summary

VDAG_01101, also known as VdHSCA, encodes a non-chaperonin molecular chaperone ATPase belonging to the Hsp70 family, with ATP hydrolase activity, ATP binding, and heat shock protein binding functions. It is annotated as a protein folding chaperone and NES receptor. In Verticillium dahliae, VdHSCA is associated with protein refolding, ER stress response, nuclear export, translation, ribosome biogenesis, and multidomain protein assembly. It localizes to the cytoplasm, cytosol, nucleus, plasmalemma, and fungal biofilm matrix. The gene is linked to numerous phenotypes including increased thermotolerance, abnormal spore germination, premature apoptosis, altered cell cycle progression through G1/S and G2/M transitions, and changes in protein transport and accumulation rates. Related genes in other species have been linked to loss of pathogenicity and hydrogen peroxide content.