ERG2 — Verticillium dahliae

Summary

VDAG_01363 (VdERG2) on chromosome DS572696 of Verticillium dahliae encodes a C-8 sterol isomerase, an ER membrane protein with isomerase activity that participates in ergosterol anabolism. The gene is associated with cellular response to xenobiotic stimulus. VdERG2 has been linked to vascular wilt disease in cotton (Gossypium hirsutum) and to germination rate and oxidative stress response. Associations with numerous cellular phenotypes include abnormal autophagy, decreased cell fusion, increased cell death, abnormal plasma membrane morphology, decreased vacuolar transport, decreased mating response, delayed shmoo formation, increased budding, decreased nutrient uptake, decreased iron and phosphorus utilization, decreased cold sensitivity, and increased starvation resistance. Studies of related genes in other species link the ERG2 family to cell membrane stability, zinc sensitivity, potassium concentration, protein content, and acid sensitivity.