CPR2 — Verticillium dahliae

Summary

VdCPR2 (VDAG_01417) of Verticillium dahliae encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) with cyclosporin A binding activity, localised to the ER lumen, fungal-type vacuole, membrane, cytoplasm and extracellular space. It is associated with protein folding and secondary metabolism. Phenotypic associations link this gene to abnormal colony colour, increased cell death, altered respiratory metabolism, increased exponential-phase growth, increased sporulation efficiency, decreased invasive growth, abnormal pseudohyphal growth, decreased osmotic stress resistance, decreased X-ray and gamma ray resistance, increased viability, abnormal endomembrane system morphology, abnormal nuclear transport, delayed endocytosis, and altered carbon source utilisation. Studies of related genes in other species link the family to reduced virulence.