CFR1 — Verticillium dahliae

Summary

VdCFR1 (VDAG_01790) in Verticillium dahliae encodes a protein containing CHS_Export/Cell_Fusion_Reg, BRCT, and FN3 domains, with protein dimerization activity, small GTPase binding, and protein binding, bridging functions. It is associated with exomer complex, TGN, Golgi, and early endosome localization, and linked to cellular bud site selection, ascospore wall assembly, conjugation with cellular fusion, chitin anabolism and breakdown, Golgi-to-plasma membrane and vacuole transport, TGN-to-endosome transport, protein transport, regulation of DNA-templated transcription, and cellular potassium and calcium ion homeostasis. Phenotype associations include absent cell fusion and biofilm formation, abnormal bipolar budding, shmoo formation, and spore wall formation, decreased endocytosis rate, absent hyperosmotic stress resistance, and increased polyploidy. Studies of related genes in other species link the family to calcium sensitivity, oxidative stress response, and protein content.